About
Clinical Evidence
How current guidelines and published research inform the way heart rhythm disorders are assessed and treated at Cyprus Arrhythmia.
On this page
Our Approach
Why Evidence Matters
Heart rhythm care changes as research develops. Diagnostic tools improve, new energy sources for ablation appear, and guidelines are updated as larger studies are completed.
Our aim is to use that evidence carefully: to choose the right test, to select a treatment that suits the rhythm disorder, and to explain honestly what is and is not known.
Evidence describes groups of patients. It cannot predict exactly what will happen to an individual, which is why every recommendation starts with a personal assessment.
Published results from a trial or a registry should therefore never be read as a promise of the outcome in a particular case.
How Evidence Is Applied
From Evidence to the Individual Plan
Matching the test to the symptoms
The choice between ECG, Holter, an event recorder or an electrophysiology study depends on how often symptoms occur and what is suspected.
Selecting the technology
Radiofrequency, cryoablation and pulsed field ablation each have a role. Selection depends on the rhythm, the anatomy and the patient.
Disease-specific strategy
Each arrhythmia has its own mechanism and target, so ablation strategies are planned individually rather than applied interchangeably. See Catheter Ablation.
Guidelines and Consensus Statements
Reference Documents by Clinical Topic
The documents below are listed as references for the corresponding topic. They are cited for orientation, and their recommendations are applied selectively to each patient.
Van Gelder IC et al. 2024 ESC Guidelines for the management of atrial fibrillation. European Heart Journal, 2024.
Tzeis S et al. 2024 European Heart Rhythm Association / Heart Rhythm Society / Asia Pacific Heart Rhythm Society / Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation. Europace, 2024.
Brugada J et al. 2019 ESC Guidelines for the management of patients with supraventricular tachycardia. European Heart Journal, 2020.
Zeppenfeld K et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal, 2022.
Technology
Published Studies on Pulsed Field Ablation
Pulsed field ablation is a newer energy source and has been studied in several major trials and registries, mainly in atrial fibrillation. The publications below are listed for reference only; their populations and devices differ, and we do not quote their figures as expectations for an individual patient.
ADVENT
Reddy VY et al. Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation. New England Journal of Medicine, 2023.
SINGLE SHOT CHAMPION
Reichlin T et al. Pulsed field or cryoballoon ablation for paroxysmal atrial fibrillation. New England Journal of Medicine, 2025.
PULSED AF
Verma A et al. Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial. Circulation, 2023.
MANIFEST-17K
Ekanem E et al. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nature Medicine, 2024.
Please Note
Information, Not Individual Advice
This page is general information and does not replace an examination, diagnosis or treatment plan. Guidelines and studies are updated over time, and the references listed here may be superseded. Your cardiologist will explain how the evidence applies to you.
Questions
Frequently Asked Questions
Does a trial result tell me what will happen to me?
Are newer technologies always better?
Where can I read more about my condition?
Continue reading